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Pulmonary function tests are a broad range tests that measure how well the lungs take in
and exhale air and how efficiently they transfer oxygen into the blood.
Spirometry measures how well the lungs exhale. The information gathered during this test
is useful in diagnosing certain types of lung disorders, but is most useful when assessing for
obstructive lung diseases (especially asthma and chronic obstructive pulmonary disease,
Lung volume measurement detects restrictive lung diseases. In this set of diseases, a person
cannot inhale a normal volume of air. Restrictive lung diseases may be caused by inflammation
or scarring of the lung tissue (interstitial lung disease) or by abnormalities of the muscles or
skeleton of the chest wall.
Testing the diffusion capacity (also called the DLCO) permits an estimate of how efficiently the
lungs transfer oxygen from the air into the bloodstream.
How the test is performed?
In a spirometry test, a person breathes into mouthpiece that is connected to an instrument
called a spirometer. The spirometer records the amount and the rate of air that is breathed in
and out over a specified time. Some of the test measurements are obtained by normal, quiet
breathing, and other tests require forced inhalation or exhalation after a deep breath.
Lung volume measurement can be performed in two ways:
The most accurate way is for a person to sit in a body plethysmograph, a sealed, transparent
box that resembles a telephone booth, while breathing in and out against into a mouthpiece.
Changes in pressure inside the box allow determination of the lung volume.
Lung volume can also be measured when a person breathes nitrogen or helium gas through a
tube for a specified period of time. The concentration of the gas in a chamber attached to the
tube is measured, allowing estimation of the lung volume. The diffusion capacity is measured
when a person breathes carbon monoxide for a very short time, often one breath. The
concentration of carbon monoxide in exhaled air is then measured. The difference in the
amount of carbon monoxide inhaled and the amount exhaled allows estimation of how rapidly
gas can travel from the lungs into the blood.